Empiric Antimicrobial Therapy in Severe Sepsis and Septic Shock: Optimizing Pathogen Clearance
نویسندگان
چکیده
منابع مشابه
Sepsis and septic shock: selection of empiric antimicrobial therapy.
This article is a brief overview of empiric antibiotic selection for sepsis and septic shock. The article includes a differential diagnosis of the mimics of sepsis and stresses a strategy for avoiding problems associated with antibiotic resistance. Although early appropriate empiric therapy is the cornerstone of sepsis and septic shock therapy, nonantibiotic interventions are critical as well. ...
متن کاملOptimizing antimicrobial therapy of sepsis and septic shock: focus on antibiotic combination therapy.
There has been little improvement in septic shock mortality in the past 70 years, despite ever more broad-spectrum and potent antimicrobials. In the past, resuscitative elements have been the primary area of clinical septic shock management and research. The question of the optimal use of antimicrobial therapy was relatively ignored in recent decades. This review explores the pathophysiology of...
متن کاملSevere sepsis and septic shock
Morbidity and mortality from sepsis remains unacceptably high. Large variability in clinical practice, plus the increasing awareness that certain processes of care associated with improved critical care outcomes, has led to the development of clinical practice guidelines in a variety of areas related to infection and sepsis. The Surviving Sepsis Guidelines for Management of Severe Sepsis and Se...
متن کاملSevere sepsis and septic shock.
From the CRISMA (Clinical Research, Investigation, and Systems Modeling of Acute Illness) Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh (D.C.A.); and the Center for Experimental and Molecular Medicine, Division of Infectious Diseases, and Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterd...
متن کاملProcalcitonin-guided therapy in severe sepsis and septic shock
We read with interest the recent systematic review of procalcitonin-guided therapy in intensive care unit patients with severe sepsis and septic shock [1]. We congratulate and applaud their important work, but several important issues should be noted. First, the authors failed to include a relevant randomized controlled trial in their meta-analysis [2], although it apparently met their inclusio...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Infectious Disease Reports
سال: 2015
ISSN: 1523-3847,1534-3146
DOI: 10.1007/s11908-015-0493-6